Benzylamine → HCID 67245096、化合物
反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][C@H:10]1[CH2:17][CH2:16][CH2:15][C@:12]2([O:14][CH2:13]2)[CH2:11]1>CO>[CH2:1]([NH:8][CH2:13][C@:12]1([OH:14])[CH2:15][CH2:16][CH2:17][C@H:10]([CH3:9])[CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
A methanol (1 ml) solution of benzylamine (5.9 g) and (3S,5S)-5-methyl-1-oxaspiro[2.5]octane (3.5 g) were heated in a microwave (100 W) for 30 minutes at 100° C., then concentrated in vacuo and purified by flash column chromatography (SiO2, 20% ethyl acetate/iso-hexane as eluent) to afford the subtitle compound as a colourless oil (4.5 g).
後処理
- concentrationconcentrated in vacuo
- custompurified by flash column chromatography (SiO2, 20% ethyl acetate/iso-hexane as eluent)
出典と根拠
- ORDレコード
- ord-efbecf2010a442b889a6f66a7034ec8f
- 出典データセット
- uspto-grants-2011_06
- 特許番号
- US07964616B2
反応ノート
読み込み中…