2H-Pyran-3(4H)-one, dihydro- → 3-(3,4-Difluorophenyl)-1,4,5,7-tetrahydropyrano[3,4-c]pyrazole

関与物質

役割	名称	HCID	仕込み量
反応物	2H-Pyran-3(4H)-one, dihydro-	HCID 90109	—
反応物	tert-butyl 3-(3,4-difluorophenyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate	HCID 59345327	—
生成物	3-(3,4-Difluorophenyl)-1,4,5,7-tetrahydropyrano[3,4-c]pyrazole	HCID 59345352	—

反応手順

Intermediate 16B was prepared according to the procedure for the synthesis of intermediate 15 by replacing 1-Boc-4-piperidone with dihydro-2H-pyran-3(4H)-one LCMS (+ESI) m/z=236 [M+H]+. 1H NMR (CDCl3) δ 7.37-7.41 (m, 1H), 7.29-7.32 (m, 1H) 7.17-7.24 (m, 1H), 4.76 (s, 2H), 3.95 (t, J=5.5 Hz, 2H), 2.84 (t, J=5.5 Hz, 2H).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08653127B2
出典データセット	uspto-grants-2014_02
ORD ID	ord-9eeb722a4bbd4e4b9834c13d9066ce4f
出典メモ	uspto-grants-2014_02