D-3-(2-Naphthyl)alanine → n-{2-[2(s)-(3-Guanidino-propyl)-5(r)-methyl-4-(2-naphthalen-2-yl-acetyl)-piperazin-1-yl]-1 (r)-naphthalen-2-ylmethyl-2-oxo-ethyl}-acetamide
反応式
[NH2:1][C@H:2]([CH2:32][C:33]1[CH:42]=[CH:41][C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:34]=1)[C:3]([N:5]1[CH2:10][C@@H:9]([CH3:11])[N:8]([C:12](=[O:24])[CH2:13][C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=2)[CH2:7][C@@H:6]1[CH2:25][CH2:26][CH2:27][NH:28][C:29]([NH2:31])=[NH:30])=[O:4].N[C@@H:44]([C:56](O)=[O:57])CC1C=C2C(C=CC=C2)=CC=1>>[NH:28]([CH2:27][CH2:26][CH2:25][C@H:6]1[CH2:7][N:8]([C:12](=[O:24])[CH2:13][C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=2)[C@H:9]([CH3:11])[CH2:10][N:5]1[C:3](=[O:4])[C@H:2]([NH:1][C:56](=[O:57])[CH3:44])[CH2:32][C:33]1[CH:42]=[CH:41][C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:34]=1)[C:29]([NH2:31])=[NH:30]参加物
3
反応物 2
生成物 1
実験手順
The following compound was synthesized by the method of Scheme 6. The compound of Example 38 was treated by the method of Example 36 to introduce an acetyl group at the amino group of the D-2-Nal residue. It was tested as described above with the results shown. The mass was analyzed as 607.7 (M+H).