4-Fluorohippuric acid → 4-fluoro-N-(2-oxo-2-(phenyl(m-tolyl)methylamino)ethyl)benzamide

反応式

[F:1][C:2]1[CH:14]=[CH:13][C:5]([C:6](=[O:12])[NH:7][CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[C:15]1([CH:21]([NH2:29])[C:22]2[CH:23]=[C:24]([CH3:28])[CH:25]=[CH:26][CH:27]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:7][CH2:8][C:9](=[O:11])[NH:29][CH:21]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:22]2[CH:23]=[C:24]([CH3:28])[CH:25]=[CH:26][CH:27]=2)=[O:12])=[CH:13][CH:14]=1

参加物

反応物 2

HCID 6993414-Fluorohippuric acid

HCID 152541551-(3-Methylphenyl)-1-phenylmethanamine

生成物 1

HCID 249002364-fluoro-N-(2-oxo-2-(phenyl(m-tolyl)methylamino)ethyl)benzamide

実験手順

Prepared in analogy to example 1.1 from 4-fluoro-hippuric acid (CA [366-79-0]) and rac-C-phenyl-C-m-tolyl-methylamine (CA [55095-20-0]).

出典と根拠

ORDレコード: ord-f3b7bd12a72046d7b2e1c0e3822842b2
出典データセット: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07964645B2

反応ノート

読み込み中…