Hydrochloride methanol → Hydrochloric Acid

HRID 2425376ノート

反応式

HRID 2425376 の反応式
C(OC([NH:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:27])=[CH:20][N:21]=[CH:22][C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.[ClH:28].CO>>[NH2:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:27])=[CH:20][N:21]=[CH:22][C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1.[ClH:28]

参加物

4

反応物 2

HCID 21893726Hydrochloride methanolHCID 67242852(S)-3-(tert-Butoxycarbonylamino)-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine

生成物 2

HCID 313Hydrochloric AcidHCID 16223985(S)-3-Amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine

実験手順

Intermediate 1a (120 mg) prepared in Step A mentioned above was added with 10% hydrogen chloride/methanol (2 ml, Tokyo Kasei Kogyo), and the mixture was stirred at room temperature for 12 hours. The solvent was concentrated under reduced pressure, and the obtained solid was collected by filtration to obtain the title compound as hydrochloride (84 mg).

後処理

  1. concentrationThe solvent was concentrated under reduced pressure
  2. filtrationthe obtained solid was collected by filtration

出典と根拠

ORDレコード
ord-00218fca87e34d048c4124cac78be506
出典データセット
uspto-grants-2011_06
特許番号
US07964613B2

反応ノート

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