Hydrochloric Acid → (3R)-3-(3-Tetrahydrofuranyl)amino-1-(4-chloro-5-isoquinolinesulfonyl)pyrrolidine

反応式

[ClH:1].[O:2]1[CH2:6][CH2:5][C:4](=O)[CH2:3]1.[NH2:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19](Br)=[CH:20][N:21]=[CH:22][C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1.C(=O)C1OC=CC=1>>[O:2]1[CH2:6][CH2:5][CH:4]([NH:8][C@@H:9]2[CH2:13][CH2:12][N:11]([S:14]([C:17]3[C:18]4[C:19]([Cl:1])=[CH:20][N:21]=[CH:22][C:23]=4[CH:24]=[CH:25][CH:26]=3)(=[O:16])=[O:15])[CH2:10]2)[CH2:3]1

参加物

反応物 4

HCID 313Hydrochloric Acid2 回

HCID 7362Furfural

HCID 5293923-Oxotetrahydrofuran

HCID 16223985(S)-3-Amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine

生成物 1

HCID 67245551(3R)-3-(3-Tetrahydrofuranyl)amino-1-(4-chloro-5-isoquinolinesulfonyl)pyrrolidine

実験手順

Hydrochloride of the compound obtained in Example 19-2 and tetrahydrofuran-3-one can be used in the method of Example 4-1 instead of hydrochloride of (S)-3-amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine and furfural, respectively, to obtain the title compound.

出典と根拠

ORDレコード: ord-7e55eb1be6634e2fb4e1a00ca552df92
出典データセット: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07964613B2

反応ノート

読み込み中…