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HRID 2425629作成日：2026年10月27日

Piperazin-2-one → 4-[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one hydrochloride

https://huagongshe.com/reaction/2425629

反応式

関与物質

役割名称HCID仕込み量
反応物Piperazin-2-oneHCID 231360—
反応物(4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chlorideHCID 57732375—
生成物4-[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one hydrochlorideHCID 67012291—

反応手順

4-[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one hydrochloride was prepared from (4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 11) and 2-piperazinone (Avocado Organics) in an analogous manner as described in example 25. LR-MS: 593.4 [(M+H)+]

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07964724B2
出典データセットuspto-grants-2011_06
ORD IDord-d21510714151407e823860999484bd9d
出典メモuspto-grants-2011_06