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HRID 2425630作成日：2026年10月27日

1-(2-Methanesulfonylethyl)piperazine dihydrochloride → [(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone hydrochloride

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反応式

関与物質

役割名称HCID仕込み量
反応物1-(2-Methanesulfonylethyl)piperazine dihydrochlorideHCID 17749885—
反応物(4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chlorideHCID 57732375—
生成物[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone hydrochlorideHCID 11563923—

反応手順

[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl-]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone hydrochloride was prepared from (4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 11) and 1-(2-methanesulfonylethyl)piperazine dihydrochloride (example 17) in an analogous manner as described in example 25. LR-MS: 685.3 [(M+H)+]

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07964724B2
出典データセットuspto-grants-2011_06
ORD IDord-8f610c47422a4a3cbe0aa8548ed00849
出典メモuspto-grants-2011_06