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HRID 2425631作成日：2026年10月27日

N,N-dimethyl-2-(piperazin-1-yl)acetamide → 2-{4-[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-dimethyl-acetamide hydrochloride

https://huagongshe.com/reaction/2425631

反応式

関与物質

役割名称HCID仕込み量
反応物N,N-dimethyl-2-(piperazin-1-yl)acetamideHCID 2758642—
反応物(4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chlorideHCID 57732375—
生成物2-{4-[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-dimethyl-acetamide hydrochlorideHCID 67012901—

反応手順

2-{4-[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-dimethyl-acetamide hydrochloride was prepared from (4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 11) and N,N-dimethyl-2-piperazin-1-yl-acetamide (Oakwood Products) in an analogous manner as described in example 25. LR-MS: 664.4 [(M+H)+]

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07964724B2
出典データセットuspto-grants-2011_06
ORD IDord-cf8c7cb35310432b8a7b5b4aac489a13
出典メモuspto-grants-2011_06