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HRID 2425640作成日：2026年10月27日

1-Acetylpiperazine → 1-{4-[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-ethanone hydrochloride

https://huagongshe.com/reaction/2425640

反応式

関与物質

役割名称HCID仕込み量
反応物1-AcetylpiperazineHCID 83795—
反応物(4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chlorideHCID 57732375—
生成物1-{4-[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-ethanone hydrochlorideHCID 67013728—

反応手順

1-{4-[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-ethanone hydrochloride was prepared from (4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 11) and 1-acetyl-piperazine in an analogous manner as described in example 25. LR-MS: 621.4 [(M+H)+]

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07964724B2
出典データセットuspto-grants-2011_06
ORD IDord-d0f3d5ef15c14122b1c72c976686879c
出典メモuspto-grants-2011_06