Ammonium Hydroxide → 1-Benzyl-4-[(4-chlorophenyl)amino]piperidine-4-carboxamide

HRID 242573ノート

反応式

HRID 242573 の反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)([C:14]#[N:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:24].[NH4+]>S(=O)(=O)(O)O>[CH2:1]([N:8]1[CH2:9][CH2:10][C:11]([NH:16][C:17]2[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=2)([C:14]([NH2:15])=[O:24])[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 704181-Benzyl-4-((4-chlorophenyl)amino)piperidine-4-carbonitrile

生成物 1

HCID 705871-Benzyl-4-[(4-chlorophenyl)amino]piperidine-4-carboxamide収率 71%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

To 1-Benzyl-4-(4-chloro-phenylamino)-piperidine-4-carbonitrile (1.97 g, 6.05 mmol) was added concentrated sulfuric acid (50 ml). The reaction stirred at room temperature as an orange homogeneous solution. After 24 hours the reaction was cooled to 0° C. and very slowly poured into concentrated ammonium hydroxide in ice. The precipitate was filtered and washed with water to give a white solid (202 mg, 71%).

後処理

  1. temperatureAfter 24 hours the reaction was cooled to 0° C.
  2. filtrationThe precipitate was filtered
  3. washwashed with water

出典と根拠

ORDレコード
ord-472db5c21c164fca93c386677e549843
出典データセット
uspto-grants-2014_02
特許番号
US08653096B2

反応ノート

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