2-Methylimidazole → N-(4-iodobenzyl)-N-valeryl-L-valine

反応式

[I:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][NH:7][C@H:8]([C:12]([OH:14])=[O:13])[CH:9]([CH3:11])[CH3:10])=[CH:4][CH:3]=1.[C:17](Cl)(=[O:22])[CH2:18][CH2:19][CH2:20][CH3:21].CC1NC=CN=1>>[I:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]([C:17](=[O:22])[CH2:18][CH2:19][CH2:20][CH3:21])[C@H:8]([C:12]([OH:14])=[O:13])[CH:9]([CH3:11])[CH3:10])=[CH:4][CH:3]=1

参加物

反応物 3

HCID 127492-Methylimidazole

HCID 61186Valeryl chloride

HCID 67247072HCID 67247072、化合物

生成物 1

HCID 67245353N-(4-iodobenzyl)-N-valeryl-L-valine収率 64%

実験手順

In a manner similar to Example 5 and starting from 800 mg (2.40 mmol) of N-(4-iodobenzyl)-L-Valine, 0.47 mL (3.84 mmol) of valeryl chloride and 296 mg (3.60 mmol) of 2-methylimidazole, 635 mg (64%) of N-(4-iodobenzyl)-N-valeryl-L-Valine is obtained. The solid is recrystallised from a mixture of EtOH:H2O 1:1.

出典と根拠

ORDレコード: ord-7a8d1d2e6c6841aa9468855acc288da2
出典データセット: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07964749B2

反応ノート

読み込み中…