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2-Ethylazepane → 1-(6-chloro-5-fluoropyrimidin-4-yl)-2-ethylhexahydro-1H-azepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Ethylazepane | HCID 4335932 | — |
| 反応物 | 4,6-Dichloro-5-fluoropyrimidine | HCID 11286675 | — |
| 生成物 | 1-(6-chloro-5-fluoropyrimidin-4-yl)-2-ethylhexahydro-1H-azepine | HCID 59341131 | 97.2% |
反応手順
0.4 g of 4,6-dichloro-5-fluoropyrimidine and 0.61 g of 2-ethylhexahydro-1H-azepine were mixed and left for 1 hour at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.6 g of 1-(6-chloro-5-fluoropyrimidin-4-yl)-2-ethylhexahydro-1H-azepine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07968537B2 |
| 出典データセット | uspto-grants-2011_06 |
| ORD ID | ord-7876b7c45ccc4da1a62657d912da03a3 |
| 出典メモ | uspto-grants-2011_06 |