Sulfuric Acid → HCID 178434679、化合物
反応式
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]#[N:9].S(=O)(=O)(O)[OH:11]>O>[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]([NH2:9])=[O:11]参加物
4
実験手順
5-Amino-3-methyl-1H-pyrazole-4-carbonitrile (15.0 g, above) was added to stirred concentrated sulfuric acid (47 mL, 95%) cooled with cold water bath. After the addition, the reaction mixture was stirred at room temperature for 2 hours before it was poured with stirring into a mixture of ice and water. The precipitate was collected by filtration, washed with cold water to remove excess sulfuric acid, and dried in a vacuum desiccator to give 5-amino-3-methyl-1H-pyrazole-4-carboxylic acid amide. (Yield 19.6 g).
後処理
- temperaturecooled with cold water bath
- additionAfter the addition
- additionwas poured
- filtrationThe precipitate was collected by filtration
- washwashed with cold water
- customto remove excess sulfuric acid
- customdried in a vacuum desiccator
出典と根拠
- ORDレコード
- ord-53df185db8b54327bf2e032e5cdc2f97
- 出典データセット
- uspto-grants-2011_06
- 特許番号
- US07968554B2
反応ノート
読み込み中…