4-(4-Chloro-phenyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester → 1-(4-Chlorophenyl)-2-methylpiperazine

HRID 242613ノート

反応式

HRID 242613 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[CH:10]([CH3:21])[CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[Cl:20][C:17]1[CH:16]=[CH:15][C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH:10]2[CH3:21])=[CH:19][CH:18]=1

参加物

3

反応物 1

HCID 667579574-(4-Chloro-phenyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 982891-(4-Chlorophenyl)-2-methylpiperazine

試薬・触媒・溶媒 1

HCID 204431481,4-Dioxane hydrochloride溶媒

実験手順

4-(4-Chloro-phenyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (0.83 g, 0.68 mmol) was dissolved in HCl/dioxane (4M, 8 mL) and stirred for 2 hr at rt. The mixture was then evaporated in vacuo, basified with aqueous sodium hydroxide (1M, 50 mL), and extracted with ethyl acetate (3×100 mL). The organic layers were evaporated and the crude residue used in the next step, (0.56 g, brown oil)

後処理

  1. customThe mixture was then evaporated in vacuo
  2. extractionextracted with ethyl acetate (3×100 mL)
  3. customThe organic layers were evaporated

出典と根拠

ORDレコード
ord-39fa8889025d47899e53e3f3ac467a7f
出典データセット
uspto-grants-2014_02
特許番号
US08653096B2

反応ノート

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