(+/-)-2a,5-Dihydropyrrolo[4,3,2-de]quinoline-2,4(1H,3H)-dione → Pyrrolo[4,3,2-de]quinoline-2,4(1H,5H)-dione
反応式
[NH:1]1[C:11]2[C:12]3[CH:3]([CH2:4][C:5](=[O:13])[NH:6][C:7]=3[CH:8]=[CH:9][CH:10]=2)[C:2]1=[O:14]>C1(C)C=CC=CC=1.[O-2].[Mn+4].[O-2]>[NH:1]1[C:11]2[C:12]3[C:3](=[CH:4][C:5](=[O:13])[NH:6][C:7]=3[CH:8]=[CH:9][CH:10]=2)[C:2]1=[O:14]参加物
4
実験手順
A mixture of (±)-2a,5-dihydropyrrolo[4,3,2-de]quinoline-2,4(1H,3H)-dione from Step C (200 mg, 1.06 mmol), and activated manganese (IV) oxide (185 mg, 2.13 mmol) was heated in toluene (3 mL) at 110° C. for 1 h. The mixture was filtered through a pad of Celite, washing with CH2Cl2:MeOH, and the filtrate was concentrated in vacuo to give the title compound. MS: m/z=187 (M+1).
後処理
- filtrationThe mixture was filtered through a pad of Celite
- washwashing with CH2Cl2
- concentrationMeOH, and the filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-81b2f8ccbad341f493457f37080aa365
- 出典データセット
- uspto-grants-2011_06
- 特許番号
- US07968540B2
反応ノート
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