Hydrochloric Acid → 1-(Benzyloxy)piperidin-2-imine hydrochloride
反応式
[CH2:1]([O:8][N:9]([CH2:17][CH2:18][CH2:19][CH2:20][C:21]#[N:22])C(=O)OC(C)(C)C)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:23]>O1CCOCC1>[ClH:23].[CH2:1]([O:8][N:9]1[CH2:17][CH2:18][CH2:19][CH2:20][C:21]1=[NH:22])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
Tert-butyl benzyloxy(4-cyanobutyl)carbamate was dissolved in a solution of 4 M HCl in 1,4-dioxane and the mixture was stirred for 18 h at room temperature. The solvent was removed under reduced pressure and the residue was treated with ethyl acetate and diethyl ether. A solid formed which was washed with diethyl ether, filtered and dried under high vacuum to give 1-(benzyloxy)piperidin-2-imine hydrochloride as a pale yellow solid.
後処理
- customThe solvent was removed under reduced pressure
- additionthe residue was treated with ethyl acetate and diethyl ether
- customA solid formed which
- washwas washed with diethyl ether
- filtrationfiltered
- customdried under high vacuum
出典と根拠
- ORDレコード
- ord-912043c672474a20bbe9a2e583b377c0
- 出典データセット
- uspto-grants-2011_06
- 特許番号
- US07968553B2
反応ノート
読み込み中…