Ethyl Acetate → 6-Nitro-2-(2,3-dihydro-1,4-benzodioxine-6-yl)-quinazoline

反応式

[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([C:14]1[CH:22]=[CH:21][C:17]3[O:18][CH2:19][O:20][C:16]=3[CH:15]=1)[N:8]=[CH:7]2)([O-:3])=[O:2].[CH3:23]COC(C)=O>>[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([C:14]1[CH:22]=[CH:21][C:17]3[O:18][CH2:19][CH2:23][O:20][C:16]=3[CH:15]=1)[N:8]=[CH:7]2)([O-:3])=[O:2]

参加物

反応物 2

HCID 8857Ethyl Acetate

HCID 578631566-Nitro-2-(1,3-benzodioxole-5-yl)-quinazoline

生成物 1

HCID 578631426-Nitro-2-(2,3-dihydro-1,4-benzodioxine-6-yl)-quinazoline収率 70%

実験手順

This compound was synthesized in 70% yield, according to the procedure described in example 1 for the synthesis of 6-nitro-2-(1,3-benzodioxole-5-yl)-quinazoline. C16H11N3O4, MW: 309.28. mp. 263-265° C.; TLC (tol/AcOEt 7/3) Rf=0.80.

後処理

customThis compound was synthesized in 70% yield

出典と根拠

ORDレコード: ord-e2d2544204e8477196eb619b4ff8ba88
出典データセット: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07968558B2

反応ノート

読み込み中…

参加物