Thiazolidinedione → HCID 86606241、化合物

HRID 2426325

反応式

HRID 2426325 の反応式
[C:1]([O:5][C:6](=[O:23])[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]2[S:17][C:18]([CH:21]=O)=[CH:19][CH:20]=2)[CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[S:24]1[CH2:28][C:27](=[O:29])[NH:26][C:25]1=[O:30].C([O-])(=O)C.[NH2+]1CCCCC1>C1(C)C=CC=CC=1>[O:30]=[C:25]1[NH:26][C:27](=[O:29])[C:28](=[CH:21][C:18]2[S:17][C:16]([C:12]3[CH:11]=[C:10]([CH:15]=[CH:14][CH:13]=3)[CH2:9][CH2:8][NH:7][C:6](=[O:23])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:20][CH:19]=2)[S:24]1

参加物

5

反応物 3

HCID 5437ThiazolidinedioneHCID 3014295Piperidinium acetateHCID 86606242Tert-butyl[3-(5-formylthiophen-2-yl)benzyl]methylcarbamate

生成物 1

HCID 86606241HCID 86606241、化合物収率 76%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 2.4 g (7.2 mmol) of tert-butyl[3-(5-formylthiophen-2-yl)benzyl]methylcarbamate, 0.85 g (7.2 mmol) of 2,4-thiazolidinedione and 0.2 g (1.4 mmol) of piperidinium acetate in 50 ml of toluene is refluxed for 4 hours in Dean-Stark apparatus. After cooling, the product precipitates. The precipitate is filtered off and washed with ethyl ether. 2.3 g (76%) of tert-butyl {3-[5-(2,4-dioxothiazolidin-5-ylidenemethyl)thiophen-2-yl]benzyl}methylcarbamate are obtained.

後処理

  1. temperatureAfter cooling
  2. customthe product precipitates
  3. filtrationThe precipitate is filtered off
  4. washwashed with ethyl ether

出典と根拠

ORDレコード
ord-2f91c4a1024d4539926f0c21b78f178d
出典データセット
uspto-grants-2011_06
特許番号
US07968560B2

関連ノート

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