反応式
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[C:19]([O:21][CH:22]([CH3:24])[CH3:23])[CH:18]=[C:17]([O:25][CH:26]([CH3:28])[CH3:27])[CH:16]=2)[CH2:10][CH2:9]1)(C)(C)C>Cl>[CH:22]([O:21][C:19]1[CH:20]=[C:15]([CH:16]=[C:17]([O:25][CH:26]([CH3:28])[CH3:27])[CH:18]=1)[CH2:14][N:11]1[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]1)([CH3:24])[CH3:23]参加物
3
実験手順
A solution of [1-(3,5-diisopropoxy-benzyl)-piperidin-4-yl]-carbamic acid tert-butyl ester (3.23 g, 7.95 mmol) in 4 M HCl (100 mL) was stirred at rt for 2 h. The hydrochloric acid was removed under reduced pressure and the crude reaction product extracted from a solution of 1 M NaOH (100 mL) with ethyl acetate (3×100 mL). The combined organic phases were dried over MgSO4 and concentrated by evaporation under reduced pressure yielding 0.78 g (32%) of a colorless oil.
後処理
- customThe hydrochloric acid was removed under reduced pressure
- customthe crude reaction product
- extractionextracted from a solution of 1 M NaOH (100 mL) with ethyl acetate (3×100 mL)
- dry with materialThe combined organic phases were dried over MgSO4
- concentrationconcentrated by evaporation under reduced pressure
出典と根拠
- ORDレコード
- ord-41c24c4fae944da7b6503db6066d160a
- 出典データセット
- uspto-grants-2011_06
- 特許番号
- US07968568B2
関連ノート
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