tert-Butyl 4-((2-chloropyrimidin-4-yl)amino)piperidine-1-carboxylate → (2-Chloro-pyrimidin-4-yl)-piperidin-4-yl-amine dihydrochloride

HRID 2426548ノート

反応式

HRID 2426548 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][N:18]=[C:17]([Cl:21])[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>C(O)C.Cl.O1CCOCC1>[ClH:21].[ClH:21].[Cl:21][C:17]1[N:16]=[C:15]([NH:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:20]=[CH:19][N:18]=1

参加物

5

反応物 1

HCID 22309647tert-Butyl 4-((2-chloropyrimidin-4-yl)amino)piperidine-1-carboxylate

生成物 1

HCID 86618538(2-Chloro-pyrimidin-4-yl)-piperidin-4-yl-amine dihydrochloride

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

A solution of 4-(2-chloro-pyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (3.2 g, 10.23 mmol) in ethanol (40 mL) and 4 M HCl in dioxane (70 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 213.3 [M+H]+.

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

出典と根拠

ORDレコード
ord-2d3dfc2119fd4ad19b6b1623a43a4062
出典データセット
uspto-grants-2011_06
特許番号
US07968568B2

反応ノート

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