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Cyclobutanone → tert-Butyl (R)-[1-(2-Fluoro-4-cyclobutylaminophenyl)pyrrolidin-3-yl]methylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclobutanone | HCID 14496 | — |
| 反応物 | Triacetoxyborohydride | HCID 2724942 | — |
| 反応物 | tert-Butyl (R)-[1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamate | HCID 68988249 | — |
| 生成物 | tert-Butyl (R)-[1-(2-Fluoro-4-cyclobutylaminophenyl)pyrrolidin-3-yl]methylcarbamate | HCID 86594882 | — |
反応手順
tert-Butyl (R)-[1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamate was alkylated with cyclobutanone using triacetoxyborohydride as reducing agent by method N. This resulted in the product with the molecular weight of 363.48 (C20H30FN3O2); MS (ESI): 364 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07968550B2 |
| 出典データセット | uspto-grants-2011_06 |
| ORD ID | ord-07e9dd52e18c463ab234649294923abb |
| 出典メモ | uspto-grants-2011_06 |