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Water → HCID 67147578、化合物

HRID 2426826
ノート
印刷プレビュー

反応式

HRID 2426826 の反応式
C(=O)([O-])[O-].[K+].[K+].[C:7]([O:11][CH3:12])(=[O:10])[CH:8]=[CH2:9].[CH3:13][O:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][C:23]=1[O:24][CH3:25])[NH:20][CH:19]=[C:18]2[C:26]1[N:34]([S:35]([C:38]2[CH:43]=[CH:42][C:41]([CH3:44])=[CH:40][CH:39]=2)(=[O:37])=[O:36])[C:29]2=[N:30][CH:31]=[CH:32][CH:33]=[C:28]2[CH:27]=1.O>CN(C)C=O.C(OCC)(=O)C>[CH3:13][O:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][C:23]=1[O:24][CH3:25])[N:20]([CH2:9][CH2:8][C:7]([O:11][CH3:12])=[O:10])[CH:19]=[C:18]2[C:26]1[N:34]([S:35]([C:38]2[CH:39]=[CH:40][C:41]([CH3:44])=[CH:42][CH:43]=2)(=[O:37])=[O:36])[C:29]2=[N:30][CH:31]=[CH:32][CH:33]=[C:28]2[CH:27]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 962WaterHCID 7294Methyl AcrylateHCID 11430Potassium CarbonateHCID 22477225HCID 22477225、化合物

生成物 1

HCID 67147578HCID 67147578、化合物

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒
HCID 8857
Ethyl Acetate
溶媒

実験手順

0.34 g of potassium carbonate and 0.243 ml of methyl acrylate are added, dropwise, to a solution of 1 g of 2-(5,6-dimethoxy-1H-indol-3-yl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine in 20 ml of anhydrous dimethylformamide, under an inert argon atmosphere at a temperature in the region of 20° C. The reaction medium is agitated at the same temperature for 16 hours. 20 ml of water and 20 ml of ethyl acetate are added. After separation by settling out, the organic phase is dried over sodium sulfate, filtered, and then concentrated under reduced pressure. After purification by flash chromatography (silica, dichloromethane as eluent, argon), the fractions containing the product are concentrated under reduced pressure. 1 g of methyl 3-{5,6-dimethoxy-3-[1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]indol-1-yl}propionate is thus obtained, the characteristics of which are as follows:

後処理

  1. customin the region of 20° C
  2. customAfter separation
  3. dry with materialthe organic phase is dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure
  6. customAfter purification by flash chromatography (silica, dichloromethane as eluent, argon)
  7. additionthe fractions containing the product
  8. concentrationare concentrated under reduced pressure

出典と根拠

ORDレコード
ord-cb99441c6ac143d18859d24742a798a3
出典データセット
uspto-grants-2011_06
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07968566B2

反応ノート

読み込み中…

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