[(2-Methylphenyl)methyl](triphenyl)phosphanium bromide → HCID 68945086、化合物

HRID 242699

反応式

HRID 242699 の反応式
[I:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[Br-].[CH3:11][C:12]1[CH:37]=[CH:36][CH:35]=[CH:34][C:13]=1[CH2:14][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>>[I:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)/[CH:5]=[CH:11]/[C:12]1[CH:37]=[CH:36][CH:35]=[CH:34][C:13]=1[CH3:14]

参加物

3

反応物 2

HCID 197738[(2-Methylphenyl)methyl](triphenyl)phosphanium bromideHCID 2526103-Iodobenzaldehyde

生成物 1

HCID 68945086HCID 68945086、化合物

実験手順

Coupling of 3-iodobenzaldehyde with (2-methylbenzyl)triphenylphosphonium bromide followed by flash chromatography (silica gel, eluent: hexanes) gave (E)-1-(3-iodostyryl)-2-methylbenzene as a colorless oil. Yield (0.498 g, 36%): 1H NMR (500 MHz, CDCl3) δ 7.87-7.86 (m, 1H), 7.59-7.55 (m, 2H), 7.45 (d, J=7.8 Hz, 1H), 7.30 (d, J=16.2 Hz, 1H), 7.23-7.18 (m, 3H), 7.09 (t, J=7.9 Hz, 1H), 6.86 (d, J=16.2 Hz, 1H), 2.43 (s, 3H) and (Z)-1-(3-iodostyryl)-2-methylbenzene as a colorless oil. Yield (0.0.540 g, 39%): 1H NMR (500 MHz, CDCl3) δ 7.47-7.45 (m, 2H), 7.21-7.15 (m, 2H), 7.11-7.01 (m, 3H), 6.85 (t, J=7.8 Hz, 1H), 6.68 (d, J=12.2 Hz, 1H), 6.49 (d, J=12.1 Hz, 1H), 2.26 (s, 3H).

出典と根拠

ORDレコード
ord-7b83c653c4e9422a87f6c172bc4d6af9
出典データセット
uspto-grants-2014_02
特許番号
US08653142B2

関連ノート

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