Ethanol → 3-[2,5-Dioxo-4-[(2-propenyloxy)methyl]imidazolidin-4-yl]benzonitrile

HRID 2427148ノート

反応式

HRID 2427148 の反応式
[CH2:1]([O:4][CH2:5][C:6]([C:8]1[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=1C#N)=O)[CH:2]=[CH2:3].O.[C-:17]#[N:18].[K+].[C:20](=[O:23])([O-])[O-].[NH4+:24].[NH4+:25].C[CH2:27][OH:28]>>[O:28]=[C:27]1[NH:25][C:6]([C:8]2[CH:9]=[C:12]([CH:13]=[CH:14][CH:15]=2)[C:17]#[N:18])([CH2:5][O:4][CH2:1][CH:2]=[CH2:3])[C:20](=[O:23])[NH:24]1

参加物

6

反応物 5

HCID 702EthanolHCID 962WaterHCID 9032Potassium CyanideHCID 517111Ammonium CarbonateHCID 86641460(2-(2-Propenyloxy)acetyl]benzonitrile

生成物 1

HCID 671310093-[2,5-Dioxo-4-[(2-propenyloxy)methyl]imidazolidin-4-yl]benzonitrile

反応条件

温度
55 °C

実験手順

To a solution of 450 mg of 3-[(2-(2-propenyloxy)acetyl]benzonitrile (in EtOH (5 mL) and water (5 mL) 291 mg of potassium cyanide and ammonium carbonate are added. The mixture is refluxed one night at 55° C. The mixture is extracted with ethyl acetate, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

後処理

  1. extractionThe mixture is extracted with ethyl acetate
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-6a5bfc1d08ce4aa281846337c9f5e2d7
出典データセット
uspto-grants-2011_06
特許番号
US07968581B2

反応ノート

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