2-(2,6-Dichloro-4-nitro-phenylsulfanyl)-benzothiazole-6-carbonitrile → 2-(4-Amino-2,6-dichloro-phenylsulfanyl)-benzothiazole-6-carbonitrile

HRID 2427219ノート

反応式

HRID 2427219 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([Cl:11])[C:3]=1[S:12][C:13]1[S:14][C:15]2[CH:21]=[C:20]([C:22]#[N:23])[CH:19]=[CH:18][C:16]=2[N:17]=1.O.O.[Sn](Cl)(Cl)(Cl)Cl>>[NH2:8][C:6]1[CH:7]=[C:2]([Cl:1])[C:3]([S:12][C:13]2[S:14][C:15]3[CH:21]=[C:20]([C:22]#[N:23])[CH:19]=[CH:18][C:16]=3[N:17]=2)=[C:4]([Cl:11])[CH:5]=1

参加物

3

反応物 2

HCID 221487332-(2,6-Dichloro-4-nitro-phenylsulfanyl)-benzothiazole-6-carbonitrileHCID 85782573Tin tetrachloride dihydrate

生成物 1

HCID 221487992-(4-Amino-2,6-dichloro-phenylsulfanyl)-benzothiazole-6-carbonitrile収率 98.2%

実験手順

The title compound was prepared using the method of example 270, starting with 2-(2,6-dichloro-4-nitro-phenylsulfanyl)-benzothiazole-6-carbonitrile (260) (1.9 g, 4.97 mmol), tin chloride dihydrate (Aldrich, 5.62 g, 24.9 mmol). Compound 272 (1.72 g, 98%) was obtained as a yellowish solid.

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-50310fc4662642eea0345bbc37606f4e
出典データセット
uspto-grants-2011_06
特許番号
US07968567B2

反応ノート

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