Nitrosylsulfuric acid → 4-Bromo-2-methoxy-6-methylbenzoic acid

HRID 2427489ノート

反応式

HRID 2427489 の反応式
[Br:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6](N)=[O:7])=[C:4]([O:12][CH3:13])[CH:3]=1.N(OS(=O)(=O)O)=[O:15]>C(Cl)Cl.O>[Br:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:15])=[O:7])=[C:4]([O:12][CH3:13])[CH:3]=1

参加物

5

反応物 2

HCID 82157Nitrosylsulfuric acidHCID 57949645HCID 57949645、化合物

生成物 1

HCID 454803864-Bromo-2-methoxy-6-methylbenzoic acid収率 96%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

4-Bromo-2-methoxy-6-methylbenzamide (2.0 g, 8.2 mmol), dissolved in CH2Cl2, was added dropwise to nitrosyl sulfuric acid (14.0 mL) in water (6.0 mL) at 0° C. and stirred for 2 hours. The reaction mixture was poured over ice and extracted with CH2Cl2, and the solvent was removed under reduced pressure to afford a light pink solid (1.93 g, 96%). 1H NMR (300 MHz, CDCl3): δ 7.07 (s, 1H), 7.00 (s, 1H), 3.93 (s, 3H), 2.46 (s, 3H).

後処理

  1. additionThe reaction mixture was poured over ice
  2. extractionextracted with CH2Cl2
  3. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-275a25ad57844f80b74d5fa2acd944ae
出典データセット
uspto-grants-2011_06
特許番号
US07968570B2

反応ノート

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