Benzoyl Peroxide → HCID 57949559、化合物

HRID 2427677ノート

反応式

HRID 2427677 の反応式
[CH3:1][O:2][C:3](=[O:16])[C:4]1[C:9]([CH3:10])=[CH:8][C:7]([Cl:11])=[CH:6][C:5]=1[C:12]([F:15])([F:14])[F:13].[Br:17]NC(=O)CCC(N)=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:16])[C:4]1[C:5]([C:12]([F:14])([F:13])[F:15])=[CH:6][C:7]([Cl:11])=[CH:8][C:9]=1[CH2:10][Br:17]

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 9834204N-BromosuccinamideHCID 579494324-Chloro-2-trifluoromethyl-6-methyl-benzoic acid methyl ester

生成物 1

HCID 57949559HCID 57949559、化合物

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A mixture of 4-chloro-2-trifluoromethyl-6-methyl-benzoic acid methyl ester (1.6 g, 6.3 mmol), N-bromosuccinamide (1.23 g, 6.93 mmol), and benzoyl peroxide (0.050 g, 0.20 mmol) in carbon tetrachloride (50 mL) was heated at reflux until majority of ester was consumed (as analyzed by GC/MS). The resulting mixture was filtered and the filtrate concentrated to afforded 2-bromomethyl-4-chloro-6-trifluoromethyl-benzoic acid methyl ester. The material was used without further purification.

後処理

  1. temperaturewas heated
  2. customwas consumed (as analyzed by GC/MS)
  3. filtrationThe resulting mixture was filtered
  4. concentrationthe filtrate concentrated

出典と根拠

ORDレコード
ord-1eeee44df6504e6cbb7c79a72d33f360
出典データセット
uspto-grants-2011_06
特許番号
US07968570B2

反応ノート

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