Benzoyl Peroxide → 2-Bromomethyl-4,6-dichlorobenzoic acid methyl ester

HRID 2427750ノート

反応式

HRID 2427750 の反応式
[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:9]([CH3:10])=[CH:8][C:7]([Cl:11])=[CH:6][C:5]=1[Cl:12].[Br:14]NC(=O)CCC(N)=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:5]([Cl:12])=[CH:6][C:7]([Cl:11])=[CH:8][C:9]=1[CH2:10][Br:14]

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 9834204N-BromosuccinamideHCID 57949430Methyl 2,4-dichloro-6-methylbenzoate

生成物 1

HCID 579493492-Bromomethyl-4,6-dichlorobenzoic acid methyl ester

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A mixture of 2,4-dichloro-6-methyl-benzoic acid methyl ester (0.71 g, 3.23 mmol), N-bromosuccinamide (0.693 g, 3.9 mmol), and benzoyl peroxide (0.012 g, 0.05 mmol) in carbon tetrachloride (20 mL) was heated at reflux until majority of ester was consumed (as analyzed by GC/MS). The resulting mixture was filtered, the filtrate was concentrated to afford 2-Bromomethyl-4,6-dichloro-benzoic acid methyl ester. The material was used without further purification.

後処理

  1. temperaturewas heated
  2. customwas consumed (as analyzed by GC/MS)
  3. filtrationThe resulting mixture was filtered
  4. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-d02f25935f2e4e34831f30b3de573bff
出典データセット
uspto-grants-2011_06
特許番号
US07968570B2

反応ノート

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