関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethylene carbonate | HCID 7303 | — |
| 反応物 | 2,6-Dichloro-4-methylphenol | HCID 17077 | — |
| 触媒 | Imidazole | HCID 795 | — |
| 生成物 | 2-(2,6-Dichloro-4-methylphenoxy)ethan-1-ol | HCID 21396902 | 75% |
反応手順
In a three-necked flask equipped with a gas droplet counter and an efficient cooling system, a mixture of 2,6-dichloro-p-cresol (20.0 g, 113 mmol), [1,3]dioxolan-2-one (9.95 g, 113 mmol) and imidazole (115 mg, 1.70 mmol) was heated to 160° C. for 25 h. The mixture was allowed to cool to rt. Purification by FC (Et2O/heptane 1.1) yielded the title compound (18.7 g, 75%). LC-MS: tR=0.88 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07968720B2 |
|---|
| 出典データセット | uspto-grants-2011_06 |
|---|
| ORD ID | ord-7c44d5c67c06435498534780c07c1f13 |
|---|
| 出典メモ | uspto-grants-2011_06 |
|---|
