Ammonium Hydroxide → 2-Oxoindoline-5-sulfonamide

HRID 24310

反応式

HRID 24310 の反応式
Cl[S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)(=[O:4])=[O:3].[OH-].[NH4+:16]>C(O)C>[NH2:16][S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)(=[O:4])=[O:3]

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 49625062-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride

生成物 1

HCID 101982322-Oxoindoline-5-sulfonamide収率 20%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

5-Chlorosulfonyl-2-oxindole (2.1 g) was added to 10 mL of ammonium hydroxide in 10 mL of ethanol and stirred at room temperature overnight. The mixture was concentrated and the solid collected by vacuum filtration to give 0.4 g (20% yield) of the title compound as an off-white solid.

後処理

  1. concentrationThe mixture was concentrated
  2. filtrationthe solid collected by vacuum filtration

出典と根拠

ORDレコード
ord-2520af5761ac4f8b8d7b07549287ce02
出典データセット
uspto-grants-2005_02
特許番号
US06855730B2

関連ノート

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