Dimethylformamide → 3-(2-Formyl-5-methyl-1H-pyrrol-3-yl)propanoic acid

反応式

[CH3:1][C:2]1[NH:6][CH:5]=[C:4]([CH2:7][CH2:8][C:9]([OH:11])=[O:10])[CH:3]=1.P(Cl)(Cl)(Cl)=O.CN(C)[CH:19]=[O:20]>>[CH:19]([C:5]1[NH:6][C:2]([CH3:1])=[CH:3][C:4]=1[CH2:7][CH2:8][C:9]([OH:11])=[O:10])=[O:20]

参加物

反応物 3

HCID 6228Dimethylformamide

HCID 24813Phosphorus oxychloride

HCID 133103523-(5-Methyl-1H-pyrrol-3-yl)propanoic acid

生成物 1

HCID 221353943-(2-Formyl-5-methyl-1H-pyrrol-3-yl)propanoic acid

実験手順

3-(5-Methyl-1H-pyrrol-3-yl)propionic acid was formylated using phosphorus oxycloride (POCl3) and N,N-dimethylformamide (DMF) to give 3-(2-formyl-5-methyl-1H-pyrrol-3-yl)propionic acid.

出典と根拠

ORDレコード: ord-fb838347cb8e4ed0add1d242a1ac99d3
出典データセット: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06855730B2

反応ノート

読み込み中…