化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Erlotinib Hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | Erlotinib | HCID 176870 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | Erlotinib Hydrochloride | HCID 176871 | 97.2% |
反応手順
10.0 g crystal form IV of erlotinib base was added to 200 ml 1,4-dioxane, heated to dissolve until being clarified, 6.4 g isopropanol saturated with HCl gas was added dropwise at 60-70° C., after dripping, stirred for 30 minutes while maintaining the temperature, stirred for 1 hour at 0-15° C. before filtration, dried at 50° C. to obtain 10.6 g sample of crystal form A. The yield was 97.2% and the purity was 99.8% (by HPLC).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08653264B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-6190bf32fedb433b972574d6bf7167e2 |
| 出典メモ | uspto-grants-2014_02 |