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HRID 243589作成日：2026年10月26日
Acetic Acid → tert-butyl(2S,3S)-2-{[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]amino}-3-methylpentanoate
https://huagongshe.com/reaction/243589
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Phthalylglycine aldehyde | HCID 76201 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | tert-Butyl isoleucinate--hydrogen chloride (1/1) | HCID 11687228 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | tert-butyl(2S,3S)-2-{[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]amino}-3-methylpentanoate | HCID 66891692 | 61.7% |
反応手順
To a solution of Example 32A (12.1 g) in methanol (20 mL) was added L-isoleucine tert-butyl ester hydrochloride (13.0 g, 58 mmol), sodium cyanoborohydride (7.3 g, 116 mmol), and acetic acid (2 mL). The resulting solution was stirred for 3 hrs at 25° C. and the methanol removed under vacuum, dichloromethane (500 mL) added, and the solution extracted with aq. NaHCO3 (2×300 mL). Evaporation and purification of the organic layer gave 12.9 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08653141B2 |
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| 出典データセット | uspto-grants-2014_02 |
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| ORD ID | ord-8ad332f9898f4d2c9e057c09c76d5c27 |
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| 出典メモ | uspto-grants-2014_02 |
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