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HRID 243598作成日：2026年10月26日
Diethylamine → methyl(2S)-3,3-dimethyl-2-{3-[(1-methyl-1H-benzimidazol-2-yl)methyl]-2-oxoimidazolidin-1-yl}butanoate
https://huagongshe.com/reaction/243598
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethylamine | HCID 8021 | — |
| 反応物 | Bis(4-nitrophenyl) carbonate | HCID 78756 | — |
| 反応物 | methyl(2S)-2-[(2-{[(9H-fluoren-9-ylmethoxy)Carbonyl][(1-methyl-1H-benzimidazol-2-yl)methyl]amino}ethyl)amino]-3,3-dimethylbutanoate | HCID 66891668 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | 1,1-Dichloroethane | HCID 6365 | — |
| 生成物 | methyl(2S)-3,3-dimethyl-2-{3-[(1-methyl-1H-benzimidazol-2-yl)methyl]-2-oxoimidazolidin-1-yl}butanoate | HCID 66890629 | 65.2% |
反応手順
A solution of the product of Example 148D (0.19 g) in N,N-dimethylformamide (3.5 mL) was treated with diethylamine (0.35 mL), stirred at 25° C. for 1.5 hours and concentrated. A solution of the residue in dichloroethane (7 mL) was treated with bis-(p-nitrophenyl) carbonate (0.128 g, 1.2 equivalents), stirred at 60° C. for 16 hours and concentrated. The residue was chromatographed on silica gel, eluting with ethyl acetate:dichloromethane (3:2) to give 80 mg (64%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08653141B2 |
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| 出典データセット | uspto-grants-2014_02 |
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| ORD ID | ord-f275c48d35fd4f29a700320587dd4070 |
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| 出典メモ | uspto-grants-2014_02 |
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