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2(5H)-Furanone, 5-hydroxy-4-methyl- → ethyl [4-methyl-6-oxopyridazin-1(6H)-yl]acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2(5H)-Furanone, 5-hydroxy-4-methyl- | HCID 115301 | — |
| 反応物 | Acetic acid, 2-hydrazinyl-, ethyl ester, hydrochloride (1:1) | HCID 11593468 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | ethyl [4-methyl-6-oxopyridazin-1(6H)-yl]acetate | HCID 77231410 | — |
反応手順
5-Hydroxy-4-methylfuran-2(5H)-one (1.19 g, 10.4 mmol) and ethyl hydrazinoacetate hydrochloride (1.61 g, 10.4 mmol) in 95% ethanol (20 mL) was refluxed for 2 h. Removal of the solvent in vacuo followed by purification using a Biotage Horizon® system (0-50% ethyl acetate/hexanes mixture) gave ethyl [4-methyl-6-oxopyridazin-1(6H)-yl]acetate as a yellow crystalline. LC/MS 219.2 (M+23).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08653260B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-3219945a94c34963a373004fac3c590c |
| 出典メモ | uspto-grants-2014_02 |