関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 5-Methylisatin | HCID 11840 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 生成物 | 5-Methylindolin-2-one | HCID 5325716 | 47.5% |
反応手順
A mixture of 5-methylisatin (15.0 g) and 60 ml of hydrazine hydrate was stirred at 140-160° C. for 4 hours. The reaction mixture was cooled to room temperature, poured into 300 ml of ice water and acidified to pH 2 with 6 N hydrochloric acid. After standing at room temperature for 2 days, a precipitate formed which was collected by vacuum filtration, washed with water and dried under vacuum to give 6.5 g (47% yield) of 5-methyl-2-oxindole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06855730B2 |
|---|
| 出典データセット | uspto-grants-2005_02 |
|---|
| ORD ID | ord-a4e1f14131e349d8b033754a9d3dbffd |
|---|
| 出典メモ | uspto-grants-2005_02 |
|---|
