HCID 57907619、化合物 → [(5S)-6,7-Dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-5-yl]methanol
反応式
C([O:20][CH2:21][C@H:22]1[N:26]2[N:27]=[CH:28][N:29]=[C:25]2[CH2:24][CH2:23]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>Cl.O1CCOCC1>[N:29]1[CH:28]=[N:27][N:26]2[C@H:22]([CH2:21][OH:20])[CH2:23][CH2:24][C:25]=12参加物
4
実験手順
The product form step B above, 0.27 g (0.71 mmol) of (5S)-5-[(trityloxy)methyl]-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole, was dissolved in 35 mL of a 4.0 M solution of hydrogen chloride in anhydrous 1,4-dioxane. The reaction mixture was stirred for 10 min, quenched with 20 mL of methanol, then evaporated to dryness in vacuo. The residue was purified by reverse phase HPLC (TMC Pro-Pac C18; 0-90% 0.1% trifluoroacetic acid in acetonitrile/0.1% trifluoroacetic acid in water gradient) to yield the title compound (0.050 g, 50%). LC-MS: m/z (ES) 140 (MH)+.
後処理
- customquenched with 20 mL of methanol
- customevaporated to dryness in vacuo
- customThe residue was purified by reverse phase HPLC (TMC Pro-Pac C18; 0-90% 0.1% trifluoroacetic acid in acetonitrile/0.1% trifluoroacetic acid in water gradient)
出典と根拠
- ORDレコード
- ord-973fc06639b2469cb576fb21ee8b5de6
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08653260B2
反応ノート
読み込み中…