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2-Chloro-6-methylnicotinic acid → 3-[1,2,3]Triazol-2-yl-pyridine-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-6-methylnicotinic acid | HCID 121724 | — |
| 反応物 | 3-Bromopyridine-2-carboxylic Acid | HCID 2050129 | — |
| 反応物 | 6-Methyl-2-[1,2,3]triazol-2-yl-nicotinic acid | HCID 67086855 | — |
| 生成物 | 3-[1,2,3]Triazol-2-yl-pyridine-2-carboxylic acid | HCID 66742288 | — |
反応手順
The title compound was prepared in a manner analogous to Intermediate 70 substituting 3-bromo-2-pyridinecarboxylic acid for 2-chloro-6-methylnicotinic acid. MS (ESI): mass calculated for C8H6N4O2, 190.10; m/z found 191.1 [M+H]+. 1H NMR (400 MHz, CDCl3): 8.77 (d, J=4.3 Hz, 1H), 8.26 (dt, J=6.5, 3.3 Hz, 1H), 7.88 (s, 2H), 7.65 (dd, J=8.2, 4.7 Hz, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08653263B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-118dfbd8519d4f50923d0036be63e290 |
| 出典メモ | uspto-grants-2014_02 |