関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-carbaldehyde | HCID 1797751 | — |
| 反応物 | N-(2-Oxoindolin-6-yl)acetamide | HCID 2749839 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-[3-(2,2-dimethylchroman-6-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-yl]acetamide | HCID 57040241 | 44.2% |
反応手順
A mixture of 6-acetamido-2-oxindole (285 mg), 2,2-dimethylchroman-6-carboxaldehyde (285 mg) and piperidine (0.2 ml) was stirred at 90° C. overnight. The reaction mixture was cooled and diluted with 20 ml of water. The sticky solid which formed was filtered and chromatographed (2% ethanol in ethyl acetate) to give 240 mg (44%) of N-[3-(2,2-dimethylchroman-6-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-yl]acetamide as an orange red solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06855730B2 |
|---|
| 出典データセット | uspto-grants-2005_02 |
|---|
| ORD ID | ord-01a3a2ad64bf410eb46cf49e157ea541 |
|---|
| 出典メモ | uspto-grants-2005_02 |
|---|
