2-(Thiophen-2-yl)benzoic acid → 2-{5-[(2-Thiophen-2-ylphenyl)carbonyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}quinoxaline

HRID 243907

反応式

HRID 243907 の反応式
[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:9]1[CH:18]=[N:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1.[S:19]1[CH:23]=[CH:22][CH:21]=[C:20]1[C:24]1[CH:32]=[CH:31][CH:30]=[CH:29][C:25]=1[C:26](O)=[O:27]>>[S:19]1[CH:23]=[CH:22][CH:21]=[C:20]1[C:24]1[CH:32]=[CH:31][CH:30]=[CH:29][C:25]=1[C:26]([N:7]1[CH2:6][CH:5]2[CH2:1][N:2]([C:9]3[CH:18]=[N:17][C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[N:10]=3)[CH2:3][CH:4]2[CH2:8]1)=[O:27]

参加物

3

反応物 2

HCID 51056232-(Thiophen-2-yl)benzoic acidHCID 610372812-(Hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-quinoxaline

生成物 1

HCID 529168462-{5-[(2-Thiophen-2-ylphenyl)carbonyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}quinoxaline

実験手順

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 35 and 2-thiophen-2-yl-benzoic acid. MS (ESI) mass calcd. for C25H22N4OS, 426.54; m/z found, 427.2 [M+H]+.

出典と根拠

ORDレコード
ord-94b810ae07f74e91a6eb9c17cdad23df
出典データセット
uspto-grants-2014_02
特許番号
US08653263B2

関連ノート

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