2,3-Dihydro-1,4-benzodioxin-5-carboxylic acid → 2-(2,3-Dihydro-1,4-benzodioxin-5-ylcarbonyl)-5-(4-phenylpyrimidin-2-yl)octahydropyrrolo[3,4-c]pyrrole

HRID 243909

反応式

HRID 243909 の反応式
[C:1]1([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([N:13]3[CH2:20][CH:19]4[CH:15]([CH2:16][NH:17][CH2:18]4)[CH2:14]3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:21]1[C:26]2[CH:27]=[CH:28][CH:29]=[C:30]([C:31](O)=[O:32])[C:25]=2[O:24][CH2:23][CH2:22]1>>[O:21]1[C:26]2[CH:27]=[CH:28][CH:29]=[C:30]([C:31]([N:17]3[CH2:16][CH:15]4[CH:19]([CH2:20][N:13]([C:9]5[N:8]=[C:7]([C:1]6[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=6)[CH:12]=[CH:11][N:10]=5)[CH2:14]4)[CH2:18]3)=[O:32])[C:25]=2[O:24][CH2:23][CH2:22]1

参加物

3

反応物 2

HCID 781842,3-Dihydro-1,4-benzodioxin-5-carboxylic acidHCID 699390982-(4-Phenyl-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole

生成物 1

HCID 529168472-(2,3-Dihydro-1,4-benzodioxin-5-ylcarbonyl)-5-(4-phenylpyrimidin-2-yl)octahydropyrrolo[3,4-c]pyrrole

実験手順

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 26 and 2,3-dihydro-benzo[1,4]dioxine-5-carboxylic acid. MS (ESI) mass calcd. for C25H24N4O3, 428.50; m/z found, 429.2 [M+H]+.

出典と根拠

ORDレコード
ord-d0ed8695be36488aab041d67532b660d
出典データセット
uspto-grants-2014_02
特許番号
US08653263B2

関連ノート

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