2-(3-fluorophenyl)benzoic Acid → 2-[(3'-Fluorobiphenyl-2-yl)carbonyl]-5-(4-methylpyrimidin-2-yl)octahydro-pyrrolo[3,4-c]pyrrole
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:15][CH:14]3[CH:10]([CH2:11][NH:12][CH2:13]3)[CH2:9]2)[N:3]=1.[F:16][C:17]1[CH:18]=[C:19]([C:23]2[C:24]([C:29](O)=[O:30])=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:20]=[CH:21][CH:22]=1>>[F:16][C:17]1[CH:18]=[C:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[C:29]([N:12]2[CH2:13][CH:14]3[CH:10]([CH2:9][N:8]([C:4]4[N:3]=[C:2]([CH3:1])[CH:7]=[CH:6][N:5]=4)[CH2:15]3)[CH2:11]2)=[O:30])[CH:20]=[CH:21][CH:22]=1参加物
3
実験手順
The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 27 and 3′-fluoro-biphenyl-2-carboxylic acid. MS (ESI) mass calcd. for C24H23FN4O, 402.46; m/z found, 403.1 [M+H]+.
出典と根拠
- ORDレコード
- ord-79611519575a4b77adf6417c1e374b1c
- 出典データセット
- uspto-grants-2014_02