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HRID 243938作成日：2026年10月27日

2-Chloro-3-methylquinoxaline → 2-[5-(Biphenyl-2-ylcarbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-3-methylquinoxaline

https://huagongshe.com/reaction/243938

反応式

関与物質

役割名称HCID仕込み量
反応物2-Chloro-3-methylquinoxalineHCID 236276—
反応物Biphenyl-2-yl-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanoneHCID 67116416—
生成物2-[5-(Biphenyl-2-ylcarbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-3-methylquinoxalineHCID 52917389—

反応手順

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 17 and 2-chloro-3-methyl-quinoxaline. MS (ESI) mass calcd. for C28H26N4O, 434.53; m/z found, 435.1 [M+H]+. 1H NMR (CDCl3): 7.85-7.72 (m, 1H), 7.65 (br s, 1H), 7.53-7.30 (m, 9H), 7.21 (d, J=10.5 Hz, 2H), 3.80-3.54 (br m, 3.5H), 3.44-3.28 (br m, 1.5H), 3.15-2.90 broad (m, 2.5H), 2.85-2.70 (br m, 1.5H), 2.65-2.50 (m, 4H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08653263B2
出典データセットuspto-grants-2014_02
ORD IDord-a848ce83012c49f0b644c4bcd2add311
出典メモuspto-grants-2014_02