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5-Fluoro-2-(pyrimidin-2-yl)benzoic acid → 2-[(5-Fluoro-2-pyrimidin-2-ylphenyl)carbonyl]-5-(4-phenylpyrimidin-2-yl)octahydropyrrolo[3,4-c]pyrrole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Fluoro-2-(pyrimidin-2-yl)benzoic acid | HCID 67086950 | — |
| 反応物 | 2-(4-Phenyl-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole | HCID 69939098 | — |
| 生成物 | 2-[(5-Fluoro-2-pyrimidin-2-ylphenyl)carbonyl]-5-(4-phenylpyrimidin-2-yl)octahydropyrrolo[3,4-c]pyrrole | HCID 52917816 | — |
反応手順
The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 26 and Intermediate 13. MS (ESI): mass calculated for C27H23FN6O, 466.52; m/z found 467.2 [M+H]+. 1H NMR (400 MHz, CDCl3): 8.72-8.66 (m, 2H), 8.44-8.29 (m, 2H), 8.16-8.02 (m, 2H), 7.53-7.45 (m, 3H), 7.21-7.14 (m, 1H), 7.10-7.06 (m, 1H), 7.01-6.98 (m, 1H), 6.87 (br s, 1H), 4.05-3.50 (m, 7H), 3.31-2.98 (m, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08653263B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-bd3657c26fb94ce3b7eca2f894b084a5 |
| 出典メモ | uspto-grants-2014_02 |