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HRID 244004作成日：2026年10月26日

5-Fluoro-2-(pyrimidin-2-yl)benzoic acid → (5-Fluoro-2-pyrimidin-2-yl-phenyl)-[5-(6-methyl-2-trifluoromethyl-pyrimidin-4-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanone

https://huagongshe.com/reaction/244004

反応式

関与物質

役割名称HCID仕込み量
反応物5-Fluoro-2-(pyrimidin-2-yl)benzoic acidHCID 67086950—
反応物2-(6-Methyl-2-trifluoromethyl-pyrimidin-4-yl)-octahydro-pyrrolo[3,4-c]pyrroleHCID 67116308—
生成物(5-Fluoro-2-pyrimidin-2-yl-phenyl)-[5-(6-methyl-2-trifluoromethyl-pyrimidin-4-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-methanoneHCID 69939310—

反応手順

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 13 and Intermediate 31. MS (ESI): mass calculated for C23H20F4N6O, 472.45; m/z found 473.2 [M+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08653263B2
出典データセットuspto-grants-2014_02
ORD IDord-293d5452ae8f4fe6b0de0359c460218a
出典メモuspto-grants-2014_02