2-(3,6-Dimethyl-pyrazin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole → [5-(3,6-Dimethyl-pyrazin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(5-fluoro-2-pyrimidin-2-yl-phenyl)-methanone

HRID 244006

反応式

HRID 244006 の反応式
[CH3:1][C:2]1[C:3]([N:9]2[CH2:16][CH:15]3[CH:11]([CH2:12][NH:13][CH2:14]3)[CH2:10]2)=[N:4][C:5]([CH3:8])=[CH:6][N:7]=1.[F:17][C:18]1[CH:19]=[CH:20][C:21]([C:27]2[N:32]=[CH:31][CH:30]=[CH:29][N:28]=2)=[C:22]([CH:26]=1)[C:23](O)=[O:24]>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:16][CH:15]3[CH2:14][N:13]([C:23]([C:22]4[CH:26]=[C:18]([F:17])[CH:19]=[CH:20][C:21]=4[C:27]4[N:28]=[CH:29][CH:30]=[CH:31][N:32]=4)=[O:24])[CH2:12][CH:11]3[CH2:10]2)=[N:4][C:5]([CH3:8])=[CH:6][N:7]=1

参加物

3

反応物 2

HCID 662104822-(3,6-Dimethyl-pyrazin-2-yl)-octahydro-pyrrolo[3,4-c]pyrroleHCID 670869505-Fluoro-2-(pyrimidin-2-yl)benzoic acid

生成物 1

HCID 67116382[5-(3,6-Dimethyl-pyrazin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(5-fluoro-2-pyrimidin-2-yl-phenyl)-methanone

実験手順

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 34 and Intermediate 13. MS MS (ESI): mass calculated for C23H23FN6O, 418.47; m/z found 419.2 [M+H]+.

出典と根拠

ORDレコード
ord-2ee0c3c9ce6e408ea090aa0d832bdf09
出典データセット
uspto-grants-2014_02
特許番号
US08653263B2

関連ノート

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