Methanol → HCID 58241680、化合物

HRID 244326ノート

反応式

HRID 244326 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4](F)[C:3]=1[I:12].[CH3:13][O-:14].[Na+].[CH3:16][OH:17]>>[I:12][C:3]1[C:4]([O:14][CH3:13])=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=1[O:17][CH3:16]

参加物

4

反応物 3

HCID 887MethanolHCID 10942334Sodium MethoxideHCID 582416821,3-difluoro-2-iodo-4-nitrobenzene

生成物 1

HCID 58241680HCID 58241680、化合物

実験手順

1,3-Difluoro-2-iodo-4-nitrobenzene (5.0 g, 17.5 mmol) was dissolved in 50 ml of methanol, and NaOMe (3.79 g, 70.1 mmol) was added. The solution was heated under reflux for 16 h. After concentration, the residue was chromatographed on silica gel using petroleum ether/ethyl acetate. This gave 2-iodo-1,3-dimethoxy-4-nitrobenzene (3 g) as a yellowish powder.

後処理

  1. temperatureThe solution was heated
  2. temperatureunder reflux for 16 h
  3. concentrationAfter concentration
  4. customthe residue was chromatographed on silica gel

出典と根拠

ORDレコード
ord-0c6fb4f4265c412494ee9877da64758b
出典データセット
uspto-grants-2014_02
特許番号
US08658569B2

反応ノート

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