4,7-Dichloroquinoline → 1-Propanol, 3-[(7-chloro-4-quinolinyl)amino]-
反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:13][CH2:14][CH2:15][CH2:16][OH:17]>O>[Cl:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:13][CH2:14][CH2:15][CH2:16][OH:17])=[CH:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1参加物
4
反応条件
- 温度
- 135 °C
実験手順
A mixture of 4,7-dichloroquinoline (25.35 g, 0.128 mol) and 3-aminopropanol (120 mL, 1.57 mol) were heated with stirring at 130-140° C. for 24 hours. After cooling, the reaction mixture was poured into water (500 mL) and filtered, and the solid residue was dried then boiled in ethyl acetate (250 mL) to give the title compound (27.3 g, 90%) as an off-white solid.
後処理
- temperaturewere heated
- temperatureAfter cooling
- filtrationfiltered
- customthe solid residue was dried
出典と根拠
- ORDレコード
- ord-fc6bfc11c84547f1b52be2d6177a1fb4
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08658648B2
反応ノート
読み込み中…