HCID 58356410、化合物 → HCID 58356391、化合物
反応式
C([O:3][CH:4](OCC)[C:5]1[S:6][C:7]([CH:15]([CH3:17])[CH3:16])=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:9]=1)C>Cl.CC(C)=O>[CH:4]([C:5]1[S:6][C:7]([CH:15]([CH3:16])[CH3:17])=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:9]=1)=[O:3]参加物
4
実験手順
A solution of ethyl 2-[bis(ethyloxy)methyl]-5-(1-methylethyl)-1,3-thiazole-4-carboxylate (430 mg) in a mixture of 10% 1M hydrochloric acid solution in acetone (50 ml) was heated at reflux for 1 h. The mixture was concentrated in vacuo, taken up in DCM (20 ml), washed with saturated sodium bicarbonate solution (10 ml), separated by hydrophobic frit and evaporated to give the title compound as a yellow oil (324 mg).
後処理
- temperaturewas heated
- temperatureat reflux for 1 h
- concentrationThe mixture was concentrated in vacuo
- washwashed with saturated sodium bicarbonate solution (10 ml)
- customseparated by hydrophobic frit
- customevaporated
出典と根拠
- ORDレコード
- ord-9f69d89128984d8d9d098b578146c644
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08658635B2
反応ノート
読み込み中…